Research & Development

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Product Pipeline

The following products are in controlled studies for the research and development of stated conditions.

Epilene®Epilepsy/Seizures, MCI- Mental Cognitive Impairment, PTSD, Cancers, Aggression, Hypertension, Peripheral Neuropathy
Procanol®ADHD, Cancers, Appetite Stimulant, Pain- Phantom Pain
IT5001cParkinson’s Disease, Multiple Sclerosis, Muscle Spacticity
IT5006bCerebral Palsy

Cannabinoid Science

Endocannabinoid System (ECS), Cannabinoid receptors, CB1 & CB2
As part of the human endocannabinoid system (ECS), cannabinoid receptors, CB1 and CB2 receptors are found predominantly at nerve terminals where they have a role in retrograde regulation of synaptic function.

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CB1 receptors are present in many areas of the brain and play a role in memory, mood, sleep, appetite and pain sensation.

CB2 receptors are found in immune cells and work to reduce inflammation. Inflammation is an immune response and is believed to be a factor in many diseases and conditions.

trans-Δ9-tetrahydrocannabinol (Δ9-THC) acts as a partial agonist at both CB1 and CB2 receptors, mimicking the effects of the endocannabinoids, which may modulate the effects of neurotransmitters (e.g. reduce effects of excitatory neurotransmitters such as glutamate).

cannabidiol (CBD) displays unexpectedly high potency as an antagonist of CB1/ CB2 receptor agonists in CB1- and CB2-expressing cells or tissues, the manner with which it interacts with CB2 receptors providing a possible explanation for its ability to inhibit evoked immune cell migration.

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Therapeutic Focus Areas

Alzheimer’s Disease

Alzheimer's disease (AD) accounts for 60% to 70% of cases of dementia. It is a chronic neurodegenerative disease that usually starts slowly and gets worse over time. The most common early symptom is difficulty in remembering recent events (short-term memory loss). As the disease advances, symptoms can include problems with language, disorientation (including easily getting lost), mood swings, loss of motivation, not managing self care, and behavioral issues.

In 2015, there were approximately 48 million people worldwide with AD.It most often begins in people over 65 years of age, although 4% to 5% of cases are early-onset Alzheimer's which begin before this. It affects about 6% of people 65 years and older. In 2010, dementia resulted in about 486,000 deaths.


Cancer, also known as a malignant tumor or malignant neoplasm, is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. Not all tumors are cancerous; benign tumors do not spread to other parts of the body. There are over 100 different known cancers that affect humans.

In 2012 about 14.1 million new cases of cancer occurred globally (not including skin cancer other than melanoma). It caused about 8.2 million deaths or 14.6% of all human deaths.[6] The most common types of cancer in males are lung cancer, prostate cancer, colorectal cancer, and stomach cancer, and in females, the most common types are breast cancer, colorectal cancer, lung cancer, and cervical cancer. If skin cancer other than melanoma were included in total new cancers each year it would account for around 40% of cases.

Cerebral Palsy

Cerebral palsy is a group of permanent movement disorders that appear in early childhood. Signs and symptoms vary between people. Often, symptoms include poor coordination, stiff muscles, weak muscles, and tremors. There may be problems with sensation, vision, hearing, swallowing, and speaking.

It is estimated that 764,000 children and adults in the U.S. manifest one or more of the symptoms of cerebral palsy. According to the Centers for Disease Control and Prevention (CDC), each year about 10,000 babies born in the United States will develop cerebral palsy.

Chronic Pain

Chronic pain is pain that persists over time (6 months or longer) and typically results from long-standing (chronic) medical conditions or damage to the body. Common sources of chronic pain include injuries, headaches, backaches, joint pains due to anarthritis condition, sinus pain, tendinitis, or overuse injuries such as carpal tunnel syndrome. Chronic pain is also a feature of many types of advanced cancers.A number of symptoms can accompany chronic pain and can even arise as a direct result of the pain. 

Chronic pain is the most common cause of long-term disability. According to the National Center for Health Statistics (2006), approximately 76.2 million, one in every four Americans, have suffered from pain that lasts longer than 24 hours and millions more suffer from acute pain.

Epilepsy / Seizures

Epilepsy is the fourth most common neurological disorder and affects people of all ages, and is a spectrum condition with a wide range of seizure types and control varying from person to person. Epilepsy is characterized by unpredictable seizures and can cause other health problems.

Epilepsy affects approximately 65 million people worldwide. In the United States 3 million people are affected by Epilepsy, and 1 in 26 people will develop this condition at some point in their lifetime.


Hypertension is a blood pressure higher than 140 over 90 mmHg (millimeters of mercury).

The number of people living with hypertension (high blood pressure) is predicted to be 1.56 billion worldwide by the year 2025.

Mild Cognitive Impairment

Mild cognitive impairment (MCI) is an intermediate stage between the expected cognitive decline of normal aging and the more serious decline of dementia. It can involve problems with memory, language, learning new things, thinking and judgment that are greater than normal age-related changes.

Multiple Sclerosis

Multiple sclerosis (MS) affects the brain and spinal cord. Early MS symptoms include weakness, tingling, numbness, and blurred vision. Other signs are muscle stiffness, thinking problems, and urinary problems. 

The Multiple Sclerosis Foundation estimates that more than 400,000 people in the United States and about 2.5 million people around the world have MS. About 200 new cases are diagnosed each week in the United States.

Muscle Spasticity

Spasticity is a condition in which certain muscles are continuously contracted. This contraction causes stiffness or tightness of the muscles and can interfere with normal movement, speech, and gait. Spasticity is usually caused by damage to the portion of the brain or spinal cord that controls voluntary movement.

Parkinson’s Disease

Parkinson's disease (PD) is a progressive disorder and belongs to a group of conditions called motor system disorders, which are the result of the loss of dopamine-producing brain cells. The four primary symptoms of PD are tremor, or trembling in hands, arms, legs, jaw, and face; rigidity, or stiffness of the limbs and trunk; bradykinesia, or slowness of movement; and postural instability, or impaired balance and coordination. As these symptoms become more pronounced, patients may have difficulty walking, talking, or completing other simple tasks.

Parkinson's affects up to 1 million people in the U.S, in which Doctors diagnose as many as 60,000 new cases each year. Parkinson's strikes 50 percent more men than women.

Peripheral Neuropathy

a condition that develops as a result of damage to the peripheral nervous system — the vast communications network that transmits information between the central nervous system (the brain and spinal cord) and every other part of the body. (Neuropathy means nerve disease or damage.) Symptoms can range from numbness or tingling, to pricking sensations (parenthesis), or muscle weakness. Common causes include systemic diseases (such as diabetes or leprosy), vitamin deficiency, medication (e.g., chemotherapy), traumatic injury, radiation therapy, excessive alcohol consumption, immune system disease, Coeliac disease, or viral infection.

An estimated 20 million people in the United States have some form of peripheral neuropathy.

Phantom Pain

Phantom pain sensations are described as perceptions that an individual experiences relating to a limb or an organ that is not physically part of the body. Limb loss is a result of either removal by amputation or congenital limb deficiency. However, phantom limb sensations can also occur following nerve avulsion or spinal cord injury.

There are an estimated 1.9 million amputees in the United States and approximately 185,000 amputations surgeries performed each year. Of those amputations performed, 82% are due to Peripheral Vascular Disease and Diabetes. It has been known that at least 80% of amputees experience phantom sensations at some time of their lives.

Post Traumatic Stress Disorder

Post-Traumatic Stress Disorder (PTSD) is an anxiety disorder that can develop after exposure to a terrifying event or ordeal in which there was the potential for or actual occurrence of grave physical harm. Traumatic events that may trigger PTSD include violent personal assaults, natural or human-caused disasters, accidents, and military combat. People with PTSD have persistent frightening thoughts and memories of their ordeal, may experience sleep problems, feel detached or numb, or be easily startled.

The U.S. Department of Veterans Affairs estimates that PTSD afflicts: Almost 31 percent of Vietnam veterans. As many as 10 percent of Gulf War (Desert Storm) veterans. 11 percent of veterans of the war in Afghanistan.